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EDITH M. ASHLEY PROFESSOR OF ORTHOPAEDIC SURGERY, HARVARD MEDICAL SCHOOL" bgTile = "" volume = "volume10" %>

Introduction

My 10th Annual Chief’s Report to the Orthopaedic Journal at the Harvard Medical School… I can’t believe it’s been a decade! During this time, the Massachusetts Institute of Technology (MIT) named a new president, Susan Hockfield, PhD, (2004) and during the past academic year, Harvard University named a new president, Drew Gilpin Faust, PhD, and in the fall we will be choosing our 44th President of the United States, and will have a new Dean at Harvard Medical School. Despite leadership changes occurring at all levels, our timehonored sustained commitment at the MGH to patient quality and safety, undergraduate and graduate medical education and Orthopaedic translational research has never been stronger.

YAWKEY CENTER FOR OUTPATIENT CARE

The Yawkey Center continues to be the shining star of outpatient programs at the MGH. Patient satisfaction with the Center is extremely high as are the conveniences including: parking, a wonderful cafeteria on the lobby-level as well an embedded Radiology Unit, Orthotics, and cast and minor procedure rooms within the Orthopaedic Center. At present we have occupied every last inch of the third-floor and half of the second floor and thus have begun to look for other ambulatory centers in the North (North Shore Center for Outpatient Care), West (MG West) and South (Brigham and Women’s/Mass General Health Care Center at Foxborough) as sites for growth.

NEW NEIGHBOR

The Liberty Hotel

After five years of construction featuring a $150 million price tag the new Liberty Hotel at the former 19th Century Charles Street Jail site on Cambridge Street opened on September 5, 2007. Heralded as Boston’s best luxury hotel, this new facility adjacent to the Yawkey building was literally carved out of Boston history and maintains the design and layout of the original architecture. The Charles Street Jail was completed in 1851 and housed inmates until May of 1990. We are pleased to have this fabulous facility so close with its wonderful meeting facilities. We have used the Liberty Hotel for patient families, visiting professors, staff meetings, and other events. Lydia Shire’s new Scampo Restaurant is fabulous!

ANOTHER NEW NEIGHBOR

Building of the 3rd Century

A new important addition to the MGH Main Campus will be the Building of the 3rd Century (B3C) which is under recent construction and will occupy the site of the former Clinics Building. The opening is scheduled for 2011 and coincides with the 200th anniversary of the MGH. The 530,000 square foot facility will house Radiation Oncology Radiology, Radiology, Inpatient and Outpatient Surgery, and 19 new operating rooms including increased Intensive Care Unit In-Patient capacity. The top-five floors will add up to 150 new beds to the institution and will increase inpatient capacity by 19% with floors dedicated to Cancer, Neurology, and Neurosurgery patients. Recently, Mr. Sumner Redstone, Executive Chairman of the Board of Directors of Viacom, pledged $35 million to develop a new Emergency Department at MGH and to relocate and expand the existing Redstone Burn Center. As I write my Chief’s Report, I can feel the reverberations from this new building’s construction and I can watch through my window the incredible machinery that is used to drive the steel supporting piles into the bedrock for the foundation for the Building of the 3rd Century. We all anxiously await this new arrival and, in particular, the expanded capacity that it will give us as a result of the thirteen new Orthopaedic OR suites. Thomas Holovacs, MD, Chairman of the OR Operations Committee states, “It is going to be awesome. This state-of-the-art facility will provide improved efficiencies with the additional operating rooms and superior digital imaging. Our Department is eagerly awaiting the Building of the 3rd Century.”


FRANCIS HORNICEK, MD, PhD, PRESENTED WITH THE BRIAN A. MCGOVERN, MD, AWARD FOR CLINICAL EXCELLENCE

Francis Hornicek, MD, PhD, Chief of the Orthopaedic Oncology Service, was among the proud recipients of the Brian A. McGovern, MD, Award for Clinical Excellence at this year’s MGPO Recognition Dinner on October 20, 2007. Dr. Hornicek along with Patricia O’Malley, MD, of Pediatric Emergency Services; and Nagagopal Venna, MD, of Neurology were presented with The Brian A. McGovern, MD, Award for Clinical Excellence, which recognizes physicians who best demonstrate the qualities that the late Dr. Brian A. McGovern embodied in clinical excellence, commitment and compassion. Dr. McGovern, a respected MGH Cardiologist who died tragically in 2003 was well known for his compassion and dedication to his patients. Dr. McGovern’s many inspirational qualities; intelligence and his good nature were all featured in a short film celebrating his achievements and his life. MGPO Chairman and Chief Executive Officer, David F. Torchiana, MD, presented each of the honorees with an engraved crystal plaque and recognized their individual achievements. Dr. Hornicek reports, “I was honored to receive the award and it is truly a privilege to work at the MGH with all of our outstanding physicians and staff.” Dr. Hornicek exemplifies all of the characteristics that make our field so special. Congratulations Dr. Hornicek, you are indeed in a class by yourself!




MANKIN PORTRAIT UNVEILING

On November 28, 2007 we unveiled a portrait and had a special Grand Rounds celebration in honor of Henry Mankin, MD, Edith M. Ashley Professor Emeritus of Orthopaedic Surgery at the Harvard Medical School. Drs. Francis Hornicek and Mark Gebhardt were the masters of ceremony for the celebration. Dr. Mankin was appointed Chief of Orthopaedic Surgery in 1972 and served in that capacity until 1996. For over 40 years, Dr. Mankin been continuously funded by the National Institutes of Health for Orthopaedic Biologic Research in the fields of cartilage and osteoarthritis research, and bone allografting. He developed a computer database system which currently contains information on over 17,000 patients and more specific information on 1200 patients who have had implanted cadaver allografts. Dr. Mankin has published 630 articles and book chapters about clinical and basic research. Dr. Mankin recently published a fabulous book entitled “Pathophysiology of Orthopaedic Disease”. Dr. Mankin has had an illustrious inimitable career and is an amazing person!

THE ORTHOPAEDIC AMBULATORY SURGERY CENTER

The Orthopaedic Ambulatory Surgery Center (ASC) at MGH West has been a spectacular success. It is a patient friendly environment and state-of-the-art facility that has been an important addition to the Department of Orthopaedic Surgery. The ASC celebrated an important milestone recently having performed the 5,000th case in June, 2008. In addition, we opened our fourth room on October 1, 2008. Over the last year, two of our new surgeons, Peter Asnis, MD, and Joseph McCarthy, MD, each started performing hip arthroscopies at the ASC. The Orthopaedic ASC is under the direction of Dr. Jeffrey Wilson, Medical Director, and Claire O’Brien, RN, MBA, CNORN, Nursing Director. The two of them have been an incredible management team and have created an environment that is dedicated to patient care, patient safety, and patient satisfaction. Recently, they began to accept Anesthesia Residents at the ASC who are taught peripheral blocks and ambulatory anesthesia. Thank you to the ASC team members, Medical Executive Committee, and Mr. David Gaynor for their oversight and management of this magnificent facility.


ANNUAL DEPARTMENT RETREAT

Our Annual Department Retreat was held May 30-31, 2008 at the wonderful Chatham Bars Inn on Cape Cod. Our Retreat occurred over a two-day period and included a Mass General Orthopaedic Associates (MGOA) Business Meeting on Day 1. This year we had a special speaker, Steven Miff, PhD, from SG-2 (Sachs Group 2) an international consulting firm with offices in Chicago, Washington, D.C. and London, who spoke on “Emerging Trends and Growth in the Future of Orthopaedic Care.” We had an open and lively discussion concerning market trends in Orthopaedics and we also had an opportunity to have several breakout sessions to discuss a variety of strategic issues in the MGOA. Day 1’s academic program was followed by a delicious Clambake and beach bonfire. Day 2 included reports by James Herndon, MD, MBA, on the state of the Harvard Combined Orthopaedic Residency Program (HCORP), Kevin Raskin, MD, on the training and teaching of the Harvard Medical Students and Mr. Richard Averbuch, Chief Marketing Officer here at the MGH gave an informative and entertaining presentation entitled, “Medical Marketing 101.” Mr. Averbuch has tremendous experience in the health care arena and provided our surgeons with a basic understanding of medical marketing; he reviewed the current draft of the MGH Department of Orthopaedic Surgery Marketing plan. The Service Chiefs and I reported on our 2007 accomplishments and reviewed their goals and objectives for 2008. We finished Day 2 with a golf tournament on the Captains Golf Course in Brewster as well as a fishing tournament directed by Captain Brian Grottkau, MD. A great time was had by all participants, and we returned refreshed and re-energized.


FACULTY UPDATES

Peter Asnis, MD, has seen incredible growth in his clinical practice as the newest member of the Sports Medicine Service. Dr. Asnis has expanded our ability to treat hip, knee, and elbow problems utilizing the newest Sports Medicine techniques. He has been actively involved in assisting Thomas Gill, IV, MD, with the care of the New England Patriots, the 2007 Eastern Division and AFC Conference Champions, who set a league record with 18 consecutive wins. In addition, Dr. Asnis works closely with the World Champion Boston Red Sox who are beginning yet another fabulous season. In other exciting sport’s news, Dr. Asnis was recently named Head Physician and Orthopedist for the Boston Bruins! Well done Peter!

Congratulations to Joseph McCarthy, MD, Vice Chair for Program Development on the recent opening of The Jim & Ellen Kaplan Center for Joint Reconstruction Surgery at the Newton Wellesley Hospital (NWH). Dr. McCarthy has been instrumental in developing an integrated joint reconstruction center at NWH that will ultimately include members of the MGOA as well as the practitioners at the NWH. In addition to the fine clinical setting, Dr. McCarthy has expanded the Harris Joint Registry at the MGH to include the NWH Arthroplasty Service and more recently has expanded the Arthroplasty Fellowship to include a fifth fellow that rotates through NWH. Dr. McCarthy’s work on total joint Arthroplasty as well as his expertise in the area of hip arthroscopies has added immensely to the Service.

In 2007, we added the newest addition, to the Harvard Medical School’s 37th Annual Advances in Arthroplasty Course, an important Pre-Course Seminar, entitled, “Hip Arthroscopy and Hip Disease in the Young.” The Pre-Course Seminar, Co-Directed Drs. Joseph McCarthy and Peter Asnis, was wildly successful with nearly 200 participants and provided an important addition to our Annual Advances in Arthroplasty Course. Dr. Asnis explains, “The First Annual Pre-Course Seminar in Hip Arthroscopy was a great success. Experts in hip arthroscopy from across the country and around the world participated in this exciting course. With this course, we were able to bring together world-class experts to discuss and debate the latest technology and advances in the field of hip arthroscopy. Hip arthroscopy is a relatively new field with great promise.”

Joseph Schwab, MD, the newest member of the Department has had an impressive first year. Dr. Schwab is a member of both the Orthopaedic Spine Center and the Orthopaedic Oncology Service. Dr. Schwab divides his time between his clinical activities in these two services and in basic science research in the area of bone and soft tissue tumors. Dr. Schwab has recently begun to collaborate with Dr. Ramnik Xavier on the molecular pathophysiology of human chordomas. The newest laboratory in the Department, The Laboratory of Sarcoma Research, includes Drs. Schwab, Zhenfeng Duan, MD, PhD, and Francis Hornicek, MD, PhD. We are pleased to have Dr. Schwab as a member of our Department and are amazed at his productivity! Dr. Hornicek reports, “Dr. Schwab has been focusing his research efforts on molecular biology of chordoma. His clinical time has been spent between the Orthopaedic Spine and Orthopaedic Oncology services. He has clinical research projects focusing on spine tumors and metastatic disease.

We welcome Joe and his wife, Christina Ferrone, MD, a physician in the MGH Department of General Surgery!

It is a pleasure to welcome Gleeson Rebello, MD, to the Department of Orthopaedic Surgery at the MGH. Dr. Rebello will be joining Drs. Brian Grottkau and Maurice Albright and the other members of the Pediatric Orthopaedic team as its newest member. Dr. Rebello did his Orthopedic Residency in India and joined the MGH as a Peabody Research Fellow in 2004; he followed with fellowships in Pediatric Orthopedics, Oncology and Hip Preservation. His expertise is in the areas of Pediatric and Adolescent Hip, Foot and Neuromuscular disorders. Dr. Rebello will be working in the newly developed North Shore Ambulatory Care Center in the MGH family and will be bringing his complicated cases to the MGH Hospital for Children on the main campus. Dr. Rebello is joined by his lovely wife Anu and their son Rahul. We wish him the best in his new role in the Department.



NEW FACILITIES

North Shore Center for Outpatient Care

The newest addition to the MGH master plan is the North Shore Center for Outpatient Care which is currently under construction and is scheduled to open in the spring of 2009. Located on Endicott Street in Danvers it is just off of Route 128. The facility will encompass the following important programs including: Orthopaedics, Cardiology, a Cancer Center and advanced imaging services as well as eight state-of-the-art surgery suites. This building conceived and constructed as a joint effort by the North Shore Medical Center (NSMC) and the MGH, is a 125,000-square-foot Outpatient Facility and an 80,000-square-foot Medical Office Building (MOB). This site will be the newest addition to the Orthopaedic Department and will offer an opportunity to partner with our North Shore colleagues to develop an important Orthopaedic Center of Excellence in the North. Mr. David Gaynor, Executive Director reports, “I look forward to working with our North Shore colleagues in developing a first class Orthopaedic practice in the Danvers Medical Office Building.” Orthopaedic Services that will initially be included in this building are Pediatric Orthopaedics, Hand and Upper Extremity, Orthopaedic Spine, Orthopaedic Oncology, Foot and Ankle. Additional services will be added in this location in the future.

BRIGHAM AND WOMEN’S/MASS GENERAL HEALTH CARE CENTER AT FOXBOROUGH

Early next year, the Brigham and Women’s/Mass General Health Care Center at Foxborough will open at the Patriot Place, a 1.3 million square foot development adjacent to Gillette Stadium, which includes shopping, entertainment and commercial properties. The health care center will consist of a four-story building of 93,000 square feet, directly in front of the main gate to the stadium, and will include physician offices, four operating rooms for outpatient surgery and advanced diagnostic imaging technology. Thomas Gill, IV, MD, will be the Medical Director for the Orthopaedic practice and physicians from our Department along with colleagues from the Brigham and Women’s Hospital (BWH) will be providing the Orthopaedic Services at this new facility. Other specialty care services including Cardiology, Dermatology, Plastic Surgery and General and Gastrointestinal Surgery will be available at this new center. Go Patriot’s Place! Go Patriots!

PRIMARY CARE ORTHOPAEDICS COURSE

The Primary Care Orthopaedics Course is a Harvard Medical School Continuing Medical Education Course run by the MGH Department of Orthopaedic Surgery for over twenty-two years. Course Director, David Ring, MD, and his Co-Directors have created incredibly broad course content to deliver the fundamentals of musculoskeletal medicine to over 120 primary care providers during their two day course. The course uses adult learning methods such as case-based panel discussions and emphasizes audience participation. This course is one of a kind and has greatly facilitated our New England regional base with our primary care colleagues. Dr. Ring states that, “The MGH Department of Orthopaedics really shines at this course. I really admire how generous and enthusiastic our very busy staff are with their time every year and they really know how to teach.”

SERVICE UPDATES

Adult Reconstructive Surgery Service (Arthroplasty)

The Arthroplasty Service under the direction of Service Chief and Department Vice Chair, Andrew Freiberg, MD, continues to grow and prosper not only on the main campus but on off-campus Newton Wellesley Hospital (NWH) facility as well. Once again the Arthroplasty Service had an outstanding presence at this year’s Orthopaedic Research Society and American Association of Orthopaedic Surgeons Annual Meetings in San Francisco, California with 19 podium presentations, posters, and exhibits. An amazing group.

Henrik Malchau, MD, PhD, has been growing his clinical practice and has been intimately involved in the establishment of multiple Clinical Databases (Registries) throughout the Department. We plan to provide evidence-based data and a clinical registry in each of our sub-divisions of Orthopaedic Surgery. This will be a critically important aspect of the future of our Orthopaedic Department and will help us better analyze our own data as it relates to other data sources throughout the region.

Dr. Malchau’s research interests include outcome documentation of primary and revision Arthroplasties with use of highly specialized radiographic tools such as RSA (Radiostereometric Analysis) and DEXA, clinical questionnaires and electronic gait activity monitoring. It is a pleasure to welcome Dr. Malchau to the Executive Committee in his new role as the Vice Chair of Orthopaedic Research at the MGH.

Close collaboration continues with the members of the Arthroplasty Service and the Bioengineering Laboratory under the direction of Guoan Li, PhD. Dr. Li reports, “We are working closely with the surgeons to apply our robotic testing system and dual-orthogonal fluoroscopic imaging techniques for the most accurate measurement of human musculoskeletal joint kinematics. Recent developments include quantification of human knee kinematics before and after surgical treatments such as total knee replacement, Anterior Cruciate Ligament (ACL) or Posterior Cruciate Ligament (PCL) Reconstruction. We are also investigating gender differences on human knee joint function and are aiming to provide baselines for the development of gender specific knee arthroplasties and for understanding the mechanisms of gender related ACL injuries.”

The Adult Reconstructive Surgery Fellowship Training Program at the MGH is one of the oldest and most renowned in the field. We hosted the 48th Year End Party of the Fellowship at the Capital Grill on Newbury Street. The 2007-2008 fellows: Michael Fehm, MD; Stefan Jobodh, MD; Alvin Mok, MD; Slade Moore, MD; and Thomas Vikoren, MD, did an outstanding job and following their graduation spread out across the country. Dr. Fehm stayed in the Boston area and is working out of the Winchester Hospital, Dr. Jibodh settled in Northern California, Dr. Mok went into practice in Redwood City, California at the Kaiser Permanente Medical Center, Dr. Moore joined a private practice Orthopaedic Group in North Carolina and Dr. Vikoren went into private practice in Doylestown, Pennsylvania. Fabulous work gentlemen!

As the Arthroplasty Service continues to grow we are in the process of searching for a new attending. This individual will have an outstanding practice both at the MGH as well the NWH along with Dr. Joseph McCarthy. The candidate list is being narrowed and I look forward to introducing our newest faculty member in my Chief’s Report in 2009.

Podiatry Service

The MGH Podiatry Service staff under the direction of Service Chief, Robert Scardina, DPM, provides ambulatory foot care, including surgery and orthotic services, at the main campus and other out-patient practice sites: Revere, Chelsea, Charlestown, the South End Community Health Center and Lynn Community Health Center. Our staff also covers inpatient consultations at the MGH and Spaulding Rehabilitation Hospital. They maintain a strong clinical relationship with the MGH Orthopaedic Foot & Ankle Service, collaborating in patient care.

The MGH Podiatry Residency Program is one of the most comprehensive podiatry post-graduate training programs in the country. The curriculum includes over twenty (one month) non-Podiatry medical and surgical rotations, broad and diverse longitudinal training experiences in clinical podiatry and foot and ankle surgery, and extensive didactic activities including new ‘on-line’ educational courseware. During academic year’07-’08, two other area hospitals joined the program as new training sites for foot & ankle surgery, increasing procedure volume and diversity and teaching faculty. We hope to soon reactivate a clerkship program for 4th year podiatric medical students across the country, helping to attract the best and brightest resident applicants. The fifth annual MGH Podiatry Service Winter Lecture, ‘Biomechanics of Human Walking: Motion Analysis Laboratory Assessment’ (guest speaker: Donna Nimec, MD) was held in January, drawing over 50 attendees including podiatrists, physical therapists, orthotic and orthopedic technicians, and medical assistants from MGH and other Partners institutions.

The MGH Podiatry Service includes seven additional attending staff members, three residents, a full-time certified orthotic technician, and two full-time medical assistants. “We value and respect our many longstanding relationships with other hospital services and departments contributing to this end, and look forward to developing new ones in the future,” notes Dr. Robert Scardina, Chief of the Podiatry Service.

Foot and Ankle Service

The Foot and Ankle service at MGH is under the leadership of Co-directors, Drs. Richard de Asla and George Theodore. The service continues to grow providing care for patients in both the Yawkey outpatient center and the MGH Sport Medicine Center on Cambridge Street. The upcoming year is likely to see the addition of a new full time faculty member as we look to expand our services in communities outside of Boston.

The service continues its relationship with the MGH Biomechanics Laboratory, under the Direction of Dr. Guoan Li. Dr de Asla’s OREF “Career Development Award” project on “In-vivo Kinematics of Posttraumatic Ankle Osteoarthritis,” saw its completion this year and was presented at a podium session at the Orthopaedic Research Society meeting in San Francisco in March 2008. The goal of the project was to better understand how ankle joint complex kinematics differs in arthritic ankles as compared to normal ankles. This understanding may have implications in future ankle joint replacement designs. We look forward to the publication.

Dr. de Asla was invited to Shanghai China to speak at the Chinese National Congress of Foot and Ankle Surgery in September of 2008. Dr. de Asla will continue to participate as an Instructional Course Lecturer at the AAOS.

The Service plans to focus on establishing a Foot and Ankle Fellowship in 2009. Watch for many important programs from this highly productive Service.

Hand and Upper Extremity Service

The Hand and Upper Extremity Service is led by Service Chief, Jesse B. Jupiter, MD. Dr. Jupiter reports a continued increase in the numbers of patients, with nearly 20% of the surgical volume of the entire Department being seen and treated by the Service.

The faculty of the Hand and Upper Extremity Service are remarkably productive in scholarly activities, presentations at regional, national, and international meetings, and are highly sought after as visiting speakers.

The Hand and Upper Extremity has become an integral part of the teaching service for upper limb trauma, hand, wrist and elbow. This year, the Hand Service has integrated fellowship rotations with the MGH Plastic Surgery Department as well as the Hand and Upper Limb Unit of the Brigham and Women’s and Children’s Hospitals making the Hand Fellowship, one of the most sought after programs in the country.

Dr. David Ring continues the multidisciplinary approach to arm illness that includes non-operative doctors (physiatrists), certified hand therapists, and a psychologist. Interest in this approach is growing within MGH and around New England. Dr. Ring reports, “The number of referrals specifically for this type of inclusive or mind/body care is increasing and they are growing a collaboration/expansion with the Orthopaedic Trauma Service. The degree to which depression, catastrophizing (interpreting symptoms in the worst ways), and heightened illness concern/health anxiety affect both pain intensity and disability is now very well established as is the role that cognitive behavioral therapy can have improving peace of mind and well being.” On the research front the program has obtained several grants and published numerous papers in the past year. The most recent data demonstrates the degree to which effective coping skills and cultivation of a positive intuition can limit objective functional impairment after injury.

The Annual Richard Smith Lectureship, now in its 19th Year, was a fabulous success. Richard Gelberman, MD, The Fred C. Reynolds Professor and Head of the Department of Orthopaedic Surgery, Washington University in St. Louis, presented the Smith Oration. His topic entitled,”The Evaluation of the Brachial Plexus,” was a wonderful summary and of special interest to the residents who attended. Each year this program offers an opportunity for individuals in the Boston Hand and Upper Extremity Community to meet and present interesting ideas, new innovative research and patient treatment modalities. The Lectureship was attended by Jane Smith, her children and other relatives of the late Dr. Richard Smith.

Shoulder Service

Dr. Jon JP Warner leads the Harvard Shoulder Service, a partnership between the Massachusetts General Hospital (MGH) and the Brigham and Women’s Hospital (BWH). Dr. Laurence D. Higgins, Director of the Sports and Shoulder Service (BWH) acts as the Fellowship Director for the Shoulder Service. Dr. Thomas Holovacs is a valuable part of the Shoulder Service at MGH and contributes to Resident and Fellowship education. This service trains 3-4 postgraduate fellows each year and hosts over 100 international visitors for varying periods of time ranging from one week to one year.

Clinical growth at the MGH has continued to be very vertical with over 900 shoulder surgeries performed by Drs. Warner and Holovacs. The core expertise of this service is the arthroscopic and reconstructive surgery for primary problems of the shoulder and the management of complex revisions of failed shoulder surgeries. Patient referrals are from the local, regional, national and international sites.

Academic highlights have included over 40 peer review publications this year. Members of this service have lectured around the world. Several especially important papers were published this year. These include:

Clavert P., Millett, PJ, Warner, JJP: “Glenoid Resurfacing: What are the limitis to asymmetric reaming for posterior erosion?” J Shoulder Elbow Surg. 2007 Nov-Dec;16(6):843-8;

Gomoll, AH, O’Toole, RV, Czarnecki, J, Warner, JJ: “Surgical Experience Correlates with Performance on a Virtual Reality Simulator for Shoulder Arthroscopy” Am J Sports Med, 2007 Jun;35(6):883-8. Epub 2007 Jan 29);

Costouros JG, Porramatikul M, Lie DT, and Warner JJP: “Reversal of Suprascapular Neuropathy Following Arthroscopic Repair of Massive Supraspinatus and Infraspinatus Rotator Cuff Tears.” Arthroscopy. 2007 Nov;23(11):1152-61;

Gobezie Reuben, Zurakowski, David, Lavery, Kyle, Millett, Peter J., Brian Cole, J., Warner, Jon J.P., “Analysis of Interobserver and Intraobserver Variability in the Diagnosis and Treatment of SLAP Tears Using the Snyder Classification” The American Journal of Sports Medicine. July 2008;

Gomoll AH, Pappas G, Forsythe B, Warner JJ. “Individual Skill Progression on a Virtual Reality Simulator for Shoulder Arthroscopy: A 3-Year Follow-up Study”. Am J Sports Med. Vol. 36, No. 6, pg. 1139-1142, 2008;

Elhassan, B., Chung, S.T., Ozbaydar, M., Diller, D., Warner, JP, “Scapulothoracic Fusion for Clavicular Insufficiency. A Report of Two Cases”. J Bone Joint Surg Am 2008:90 875-880.

This year Dr. Warner was named President of The New England Shoulder and Elbow Society (www. neses.com), a forum for shoulder and elbow surgeons around New England to gather in a collegial environment and discuss and argue about the best methods of treatment for shoulder and elbow problems. The 2008 Annual Meeting was held in Jay Peak, Vermont. Over 140 surgeons attended the two-day event. Recently the world’s largest live shoulder surgery course was held in Annecy, France and Dr. Warner was one of 40 International Faculty who performed 33 live surgeries in 3 days in front of an audience of 750 shoulder surgeons.

Other major developments include a new patient database, which allows for prospective documentation of operative cases and preoperative as well as postoperative outcome for treatment of shoulder problems. Our Educational Database is also growing to over 260 GB of videos, case studies, and case documentations.

This year’s fellows have been very successful with their job hunt. Dr. Robert Rolf will go into private practice in Cincinnati, Ohio. Dr. Darren Friedman will go into private practice at NYU in New York City, and Dr. Nata Parnes will continue his postgraduate work in Europe as well as with Dr. Jupiter here at MGH.

Orthopaedic Oncology Service

The Orthopaedic Oncology Service is under the able direction of Service Chief, Francis Hornicek, MD, PhD. Members of the Orthopaedic Oncology Service have been the pioneers in the area of transplantation in limb sparing procedures in bone cancer patients and musculoskeletal oncology.

The Orthopaedic Oncology Service and the members of the Medical and Radiation Therapy Service from the Center of Sarcoma and Connective Tissue Oncology, part of the MGH Cancer Center, provide comprehensive care for patients with soft tissue sarcomas. They are a regional, national and international referral center for these complex tumors. Dr. Dempsey Springfield recently joined the service and has added enormous depth to the areas of Resident and Fellow Education, as well as the treatment of complex intra-pelvic sarcomas. Dr. Kevin Raskin, Dr. Dempsey Springfield, Dr. Joseph Schwab and Dr. Hornicek continue to divide their clinical service with addi- tional passions including orthopaedic research and medical student and resident education. Dr. Hornicek and Zhenfeng Duan, MD, PhD, run the Molecular Sarcoma Laboratory and have multiple collaborative efforts to study tumor agenesis and stem-cell research on tumor pathogenesis.

The Musculoskeletal Tumor Fellowship, one of the mostsought after in the country, brings together members of Beth Israel Deaconess, The Children’s Hospital and the MGH to develop a truly world-class Fellowship program. The Orthopaedic Oncology group has a truly impressive past, a highly productive present and a future that includes innovation in many areas!

Sports Medicine Service

In October 2006, the Sports Medicine Service moved to its new location on Cambridge Street. This new state-of-the-art facility, MGH Sports Medicine Center, houses physician offices, exam rooms, Radiology, Cast and Bracing, a library, conference center and an ultra-modern physical therapy and rehabilitation suite.

Thomas Gill, IV, MD, Chief of the Sports Medicine Center and Medical Director of the new Center, reports that they are building a comprehensive and integrated Sports Medicine Service as part of the Department of Orthopaedic Surgery. This Center gives patients access to Orthopaedic Sports Medicine, Foot and Ankle Surgery, Radiology, Physical Therapy, Bracing and primary care. Larry Ronan, MD, of the Internal Medicine Associates has been active in establishing the Primary Care Sports Practice in the Center. Dr. Gill continues his roles as Medical Director for the Boston Red Sox, a position he was named to in 2005 and Head Team Physician for the New England Patriots since 2006.

Dr. Peter Asnis joined the Sports Medicine Service staff in 2006. He specializes in Sports Medicine and arthroscopic surgery for hip disease. Dr. Asnis continues to expand his care and his work and he continues to work as a team physician for the Boston Red Sox, New England Patriots, the New England Revolution and he was recently, named Head Team Physician for the Boston Bruins. In addition, to his flourishing clinical practice, Dr. Asnis is active with the Bioengineering Laboratory at Massachusetts General Hospital where research is performed to optimize treatments for patients with sports related injuries.

The newest member of the MGOA, Bertram Zarins, MD, continues his tradition of excellence in the area of Sports Medicine. Dr. Zarins has been on staff at the MGH for 35 years and in September 2006, was named the first Augustus Thorndike Professor of Orthopaedic Surgery at Harvard Medical School and the Massachusetts General Hospital. Dr. Zarins, like Dr. Thorndike, a pioneer in the field of Orthopaedic Surgery, will continue to focus his energies in Orthopaedic education, clinical care, and the development of new patient care models and educational paradigms for tomorrow’s sports medicine practitioners. Dr. Zarins reports, “The new Sports Medicine Center has allowed the Sports Medicine Service to grow and to improve patient care. We have been able to greatly increase clinical and basic research. The conference room and library provide improved educational facilities. We are currently developing an arthroscopy simulation learning center.”

ORTHOPAEDIC SPINE CENTER

The Orthopaedic Spine Center at the MGH is under the skillful direction of Kirkham B. Wood, MD, and now in its 9th year of existence. All aspects of spine care, teaching, and research are under the auspices of this service. Our Multidisciplinary Orthopaedic Spine Center includes: Attendings, Kirkham Wood, MD; Joseph Schwab, MD; and Physiatrists: James Sarni, MD; Leonid Shinchuk, MD; and David Binder, MD. In addition, James Rathmell, MD, an anesthesiologist with the MGH Pain Center works closely with this multidisciplinary program to provide a full breadth of services to our patients.

Dr. Joseph Schwab, the newest member of this division, is a member of two services, the Orthopaedic Oncology Service and the Orthopaedic Spine Center. Dr. Schwab’s work and interest is in metastatic disease of the spine, primary spine tumors, and bone and soft-tissue tumors. Dr. Schwab is integrating a highly active clinical practice along with his clinical practice in Orthopaedic Oncology.

The Combined Harvard Spine Fellowship (BWH attendings, Drs. Mitchell Harris and Christopher Bono) has three fellows (2 at MGH, and 1 at BWH). The fellows are actively involved in teaching and research programs in addition to their clinical duties. In addition, Dr. Wood reports, that, “We have now embarked on a fellowship and research exchange program with the Peking University Hospital as Chinese spine surgeons visit the MGH and participate in clinical and basic science research.”

Dr. Kirk Wood and Dr. Guoan Li, Director of the Bioengineering, have been collaborating actively in the area of Spine Kinematics. Dr. Wood is using the Dual-Fluoroscopic Kinematics system to better study the kinematics of the cervical and lumbar spine. Dr. Li explains, “The implication of this work is to better provide excellent kinematics’ data as we move into the field of disc replacement surgery.” In addition, Dr. Wood has developed a spinal database along with Henrik Malchau, MD, PhD and has been named the Co-Chair for the Adult Spine Deformity Committee of the Scoliosis Research Society.

RESEARCH UPDATES

Bioengineering Laboratory

The Bioengineering Laboratory under the direction of Guoan Li, PhD, continues it tradition of innovation in the area of joint engineering and biomechanics. This year they have begun to report their in-vivo data using their dual-orthogonal fluoroscopic imaging technique for the accurate measurement of in-vivo joint kinematics. This cutting-edge technique along with the validation from the robot testing system is being utilized to provide new concepts in Total Knee Arthroplasty, Unicompartimental Knee Arthroplasty, knee ligament reconstruction, upper extremity reconstruction, and the exciting area of adult spine kinematics.

Richard de Asla, MD, and Michal Kozanek, MD, of the Bioengineering Lab recently completed a study comparing the kinematics of the healthy versus osteoarthritic ankles. Dr. de Asla presented at this year’s Foot and Ankle Society Meeting his important work on “In-vivo Kinematics of Post- Traumatic Ankle Osteoarthritis.” Utilizing the Bioengineering Laboratory’s dual-orthogonal fluoroscopic imaging technique, he found that the motion coupling between a healthy ankle and the subtalar joint is reversed in the presence of osteoarthritis of the ankle. This finding may have implications in future ankle surgery and joint replacement designs.

Recent development has been achieved on in-vivo human spine research. The team is working in close collaboration with Drs. Kirkham Wood and Brian Grottkau, to detect the effect of scoliosis fixation on adjacent vertebral disc degeneration. They are trying to quantify the biomechanical mechanism of intervertebral disc deformation in normal and lower back pain patients during daily activities. They are also working to understand how current spinal fusion and disc replacement in place today affect disc degeneration in adjacent vertebral levels. Dr. Wood was recently awarded a grant from the North America Scoliosis Society to investigate Biomechanics of scoliosis patients. This group has recently submitted their application to NIH for investigation of lumbar spine fusion biomechanics.

Dr. Lu Wan, recently received his PhD in Bioengineering (MIT). His thesis was the first to investigate the in-vivo articular contact mechanics of human ankle joints. His work has been well reviewed in the literature including the Journal of Osteoarthritis and Cartilage, Journal of Orthopaedic Research, and the Journal of Biomechanics.

The lab has an increasing contingent of outstanding graduate students from MIT, including Daniel Massimini, Ali Hosseini, Shaobai Wang, and Kartik Varadarajan, and postdoctoral fellows, including Drs. Samuel van de Velde, Gang Li, Michal Kozanek, Qun Xia, Fan Liu, Jong Keun Seon and Eric Fu. Dr. Kozanek has been studying in-vivo OA ankle joint kinematics in collaboration with Dr. Richard de Asla and investigating in-vivo dynamic knee kinematics in collaboration with Drs. Rubash and Gill. Mr. Massimini continues to conduct research on in-vivo human shoulder biomechanics in collaboration with Dr. JP Warner as part of his Master’s degree thesis. Mr. Hosseini, who recently passed his PhD qualifying examination continues to investigate in-vivo ACL tension using advanced imaging and robotic technology in collaboration with Dr. Thomas Gill for his PhD. Drs. Xia, Li and Mr. Wang are actively studying intrinsic biomechanics of human lumber spine in collaboration with Drs. Kirkham Wood and Brian Grottkau. Mr. Varadarajan made enormous progress in the investigation of “genderrelated” in-vivo biomechanics of knee and the effect of implant development in collaboration with Drs. Freiberg and Rubash. Kartik Varadarajan, and co-authors won the Second Place in PhD American Society of Mechanical Engineer’s (Marco Island, Florida, June, 2008) student paper competition, for the work entitled, “In-vivo kinematics and contact forces of the knee after TKA” Dr. Samuel van de Velde, is actively publishing on in-vivo PCL biomechanics. Dr. Fu has successfully completed a first in-vivo human forearm kinematics study using the imaging technique. Angela Moynihan and Hemanth Reddy Gadikota are our core bioengineers and have actively participated in a variety of clinical and robotic projects, including in-vivo ACL/ PCL and in-vivo TKA.

The team had over 20 talks, podium presentations, posters and symposiums at this year’s ORS/AAOS, and Bioengineering meetings. They published 19 papers and have 16 additional papers accepted for publication or under peer review in biomechanics journals over the last year and continue their enormously successful path in the area of joint bioengineering.

The Harris Orthopaedic Biomechanics and Biomaterials Laboratory (HOBBL)

The Harris Orthopaedic Biomechanics and Biomaterials Laboratory (HOBBL) is under the co-direction of Orthun Muratoglu, PhD, and Henrik Malchau, MD, PhD. Members of this laboratory have contributed to the field of Adult Reconstructive Surgery for over four decades. A variety of different topics have been studied and major contributions have been made particularly in the area of implant stability, implant fixation, bearing-surface applications, and 1st, 2nd and now 3rd Generation of highly crosslinked polyethylenes. Currently, there are a number of outstanding clinical projects underway at the HOBBL. Dr. Charles Bragdon is leading a staff to study the clinial performance of first generation highly cross-linked polyethylene and the newly FDA approved vitamine-E doped polyethlene for use in hip and knee arthroplasties. Dr. Bragdon has been in the laboratory for over two decades. Charlie and I did the first canine hip replacement in the mid-eighties!

An additional clinical outcomes study in its 7th year utilizes RSA techniques to determine the wear behavior of crosslinked polyethylene in conjunction with the traditional as well as large heads. This study has shown marked reduction in wear and femoral head penetration at the 7th year benchmarks. Dr. Malchau and co-investigators are quite pleased with these results and state, “So far the first generation highly crosslinked polyethylene performs as predicted in the preclinical experiments and seems to be the bearing of choice in the active patient.”

The HOBBL is also focusing on materials including crosslinked polyethylene with low-wear and high strength for applications in hip, knee and other joint arthroplasties. This section of the HOBBL is under the direction of the Orhun Muratoglu, PhD, an innovator in this field for over a decade. The newest technology utilizes Vitamin E to stabilize the residual freeradicals and to plastersize the base polymer in the second generation polyethylene. Ebru Oral, PhD, and a group of scientists along with Dr. Muratoglu are leading this important area of investigation.

New exciting areas of collaboration include the area of knee wear. Drs. Orhun Muratoglu, Henrik Malchua, Guoan Li, and I, as well as Lars Weidenhielm, MD, PhD, and Eva Weidenhielm- Broström, PhD, scientists who joined us from Sweden in early September will be tackling the difficult and perplexing problem of knee wear. This project will provide some exciting information with the ultimate goal of detecting in-vivo wear as it relates to implant longevity. Dr. Li states, “The innovative dual fluoroscopic technique in a combined effort with HOBBL, is being developed to detect in-vivo poly wear to predict longevity of patients after TKA.”

Another new area of collaboration for HOBBL is in the area of spine kinematics and spine reconstruction. The team is working on technology using hydrogels as materials for intervetebral disc replacement along with biodegradable polymer technology. These studies could benefit many of our patients with degenerative axial-skeleton disease as well as spinal deformity. Dr. Kirkham Wood states, “On going studies in the Biomechanics Lab include projects studying the three-dimensional analysis of intervertebral disc motion using a combined MRI-fluroscopic technique; the effects of disc degeneration on in-vivo disc deformation and the effect of spinal deformity surgery on adjacent segment vetebral kinematics using noninvasive techniques.”

The HOBBL is a source of enormous activity and energy in the area of translational and basic science research. The skillful scientists in this laboratory had another incredible year at the ORS and the AAOS with over 20 abstracts presented. Once again the members of this outstanding laboratory have added a tremendous amount of new knowledge to our field. I know that these important contributions will continue in the future.

Laboratory of Biochemistry and Osteoarthritis Therapy

Teresa Morales, PhD, directs the Laboratory of Orthopaedic Biochemistry and Osteoarthritis Therapy. A major interest of the group is centered on the Insulin-like Growth Factor (IGF) Axis, since this is a major regulator of matrix metabolism in human articular cartilage. Dr. Morales and her team published several papers this year relating to their work on the actions of the IGFs and the related binding proteins (IGFBPs) in normal and osteoarthric (OA) human cartilage. These papers documented several important findings including that OA cartilage is able to respond to the anabolic IGF stimulus while being tempered by the IGFBPs--which are elevated during disease (Morales, 2007, JOR 26:465). Moreover, the wide distribution of IGFBP-3 in the extracellular matrix and inside the cell nucleus was definitively shown in an OA and Cartilage paper (Hunziker et al, 2008, 16:185) using a variety of elegant and complementary methods including high resolution, fluorescence immunohistochemistry, gold labeling electron microscopy and cell fractionation studies (Sun et al, 2008, JOR DOI 10.1002/jor 20660). The papers discussed the concept that the extracellular pools of IGFBP-3 are likely to participate in IGF regulation, while the intra-nuclear protein is likely to be involved in IGF-independent gene regulatory actions. The group is now studying the potentially critical interactions of nuclear IGFBP-3 with non-steroidal hormone receptors such as the Vitamin A derivatives (retinoic acid) and vitamin D elements, which are known to interact with the binding protein in other cell types. Interest in Vitamin A is enhanced by the fact that it is well known that its retinoic acid derivative leads to cartilage degradation in-vitro and more recent studies of rodents show that administration of retinoic acid leads to cartilage atrophy. Dr. Morales also authored a comprehensive review and analysis of current knowledge on cartilage cell movements (Morales, OA and Cartilage 2007, 15: 861), which is another topic of interest to the group. She keeps actively involved with the NIH and recently accepted their invitation to be a grant reviewer this fall in her former study section, Arthritis Connective Tissues and Skin (ACTS).

Laboratory of Musculoskeletal Engineering

The Laboratory for Musculoskeletal Tissue Engineering, under the direction of Mark Randolph and Dr. Thomas Gill, focuses on cartilage repair and regeneration in the knee. Previous work funded by the AO Foundation focused on tissue engineering strategies to repair lesions in the avascular regions of the meniscus. The results demonstrated an efficient means to seed chondrocytes onto polygalactin (PLGA) scaffolds, and the capacity of this cell-scaffold constructs to heal buckethandle lesions in swine meniscus. This study was published in November in the American Journal of Sports Medicine in November 2006 (Weinand C, et al, 2006, 11:34). Current studies funded by the NFL Charities are focusing on translating these findings from animals to preclinical studies using human chondrocytes for cartilage healing and regeneration.

The group also continues to explore new hydrogels for articular cartilage repair and regeneration. Working with Drs. Robert Redmond and Irene Kochevar from the Wellman Center of Photomedicine, they have developed a novel means to photocrosslink collagen gel for use as an encapsulation gel for chondrocytes and neocartilage formation. This work was published in Tissue Engineering in 2007 (Ibusuki S et al, 13:8). In collaboration with Dr. Kristi Anseth, at the University of Colorado, the group has been exploring photoactive substances that can form hydrogel scaffolds for cartilage formation, specifically poly (ethylene glycol). Results of this were presented at the Orthopedic Research Society in San Diego, California, in March 2007. New studies in collaboration with Dr. Orhun Muratoglu in the Department’s Orthopedic Biomechanic and Biomaterials Laboratory are exploring a hybrid scaffold composed of nondegradable poly(vinyl alcohol) scaffold combined with chondrocytes for joint cartilage replacement.

Pediatric Orthopaedic Tiss ue Engineering Laborato ry; Our Newest Laboratory!!

The division of Pediatric Orthopaedics under the direction of Brian Grottkau, MD, remains actively involved in clinical and basic science research. Over the past year we have established a Pediatric Orthopaedic Tissue Engineering Laboratory. Dr. Chuan Ye spent one year in the lab for tissue engineering as a fellow and completed a POSNA sponsored study on mesenchymal stem cell transplantation for the treatment of Legg- Calve-Perthes disease. The team hopes to present this data at the POSNA meeting in Boston in 2009. A new postdoctoral fellow, Yunfeng Lin, D.D.S., Ph.D., will be joining the group in November, 2008. Dr. Lin is an accomplished tissue engineering researcher from China who will carry on the laboratory’s mission to expand the knowledge and orthopaedic applications of tissue engineering over the next 3 years. They have also completed enrollment in two prospective, randomized industry sponsored studies on wound closure following scoliosis surgery and bilateral lower extremity surgery in children. The team hopes to have the data analyzed, presented and published within the next six months. Congratulations to Dr. Grottkau on the development of this important new laboratory!

Sarcoma and Molecular Biology Laboratory

The Sarcoma Molecular Biology Laboratory (SMBL), under the direction of Zhenfeng Duan, MD, PhD and Francis J. Hornicek, MD, PhD, is working on understand the mechanisms of multi-drug resistance, identification of small molecules and targets to reverse drug resistance, and characterization of molecular mechanisms governing growth, proliferation of human chordoma cells.

Dr. Duan explains, “Our laboratory investigates novel approaches to further advance the treatment of human cancer. The overall objectives of our laboratory are to explore biological mechanisms of tumors arising in bone and other tissues. One of the major focuses of the lab is to elucidate the mechanisms of the development of drug resistance in cancer. In addition, translational research into new treatment options for sarcoma patients has been undertaken. Continued collaboration with other institutions and pharmaceutical companies has provided the foundation for evaluation of new drug development. Many of these drugs are derived from marine sources and their corresponding biochemical structures are quite complex.” The Sarcoma Molecular Biology Laboratory has published articles pertaining to multiple drug resistance in human cancer, sarcoma biology and has received funding from a variety of sources including NIH, foundations, corporate sponsors, and benefactors.

The sarcoma research group at the MGH includes investigators from multiple disciplines, as does the clinical group. We hope to continue research expansion and further collaboration within the Harvard community. We look forward to many important contributions from this new laboratory.

Laboratory Updates and Renovations

Henrik Malchau, MD, PhD, and the Executive Committee of the Department have begun a planning phase for the reorganization of our Orthopaedic Laboratories. This plan has been under review and has made its way through the Executive Committee as well as the Laboratory Council. In an attempt to focus our translational research activities and to accommodate new areas of research in Orthopaedic Surgery including mesenchymal stem-cells, Orthopaedic Oncology, and joint reconstruction a multi-year laboratory renovation program has begun. More to come!!!

DEPARTMENT HOLIDAY PARTY

This year’s annual black tie Department Holiday Party was held at Boston’s Museum of Fine Arts. We had nearly 400 revelers in attendance. Everyone enjoyed the festive music, decor, and of course the delicious array of foods. Many attendees toured through the museum’s special exhibit on display, “Symbols of Power: Napoleon and the Art of the Empire Style, 1800-1815.” Plans are underway for next year’s holiday party, which will be held at the luxurious Seaport Hotel in South Boston on December 20, 2008.

CHILDREN’S HOLIDAY PARTY

Our 8th Annual Children’s Holiday Party was held at the Boston Children’s Museum. Children and their families were greeted by an elf and entertained with holiday stories and a magic show. After enjoying lunch, Santa and Mrs. Claus joined the party and met with each child to hear their special Christmas wishes. All the children left with gift from Santa and time to explore the newly renovated museum and its’ wonderful interactive exhibits. Next year’s Children’s Party will be held at The Intercontinental Hotel in Boston and will bring with it the magic of the Polar Express and other new traditions for the children and their families.



PERSONAL NOTE

We reached some significant milestones this year. I have been at the MGH for a decade, I am in my 25th year of practice of Orthopaedic Surgery, and Kimberly and I celebrated our 30th wedding anniversary in August… Wow! As I reflect upon these three significant milestones some important concepts and similarities emerge. The first is the enormous importance of family whether it is your colleagues, your friends, or your spouse and children. Hard work, dedication, joy, tribulations, and successes of your immediate and extended family are the essential ingredients that contribute to the longevity of relationships. The second concept is trust. Trusting the commitment of others, their dedication to a practice, to an institution, to a family, or to an individual, forms a foundation on which key relationships are built. Finally, love… Love of a child, a spouse, an associate, a friend or relative, or an institution forms the bedrock of the foundation by which we exist.

Our family reached a new milestone this fall as Kristin, our youngest, began her collegiate career at Wheaton College in Norton, Massachusetts. Kristin weighed her opportunities and decided that Wheaton represented the best education, class structure and campus size for her goals, aspirations and equestrian prospects. Kristin’s intellect, her enormous strength, and her past, should prepare her for a wonderful collegiate experience.

Steve finished the School of General Studies at Boston University and has entered the Management Program there. He is extremely excited about pursuing this career path and he is doing well in his fall classes. Steve completed all of the requirements this summer and performed in an outstanding fashion. In the future he wants to build “buildings”… I have never met anyone with this career goal.

Brad entered his senior year at Rollins College in Florida and he has been able to successfully blend his academic pursuits with his extreme love of swimming. He has had an enormously successful career in swimming and plans to use his Anthropology major as a foundation for graduate studies next fall.

Kimberly and I are looking forward to our first year as “empty nesters”. Our children are concerned about our health and well-being and each has asked, “How will we manage with all three of the children out of the house?” Don’t worry a bit, we’ll be OK! We are looking forward to spending some time together, pursuing outside interests, and continuing our education. We also hope to spend a week in Tuscany, Italy later this fall to celebrate our 30th wedding anniversary.

Thank you all for helping me to reach these important milestones! I am pleased and honored to be your Chairman.